Stem cell research which could reduce the need
for liver transplants has been revealed. Scientists
are investigating whether people suffering from liver disease could
be treated using embryonic stem cells.
The research is one of two projects at the University
of Edinburgh which has received £3.6 million from Scottish
Enterprise, the Medical Research Council and the UK Stem Cell Foundation.
It will focus on how liver cells (hepatocytes) derived
from embryonic stem cells can be used in therapies for acute and
chronic liver disease.
Scientists will investigate how the stem cells differentiate
to become liver cells, and how these can be made to repair damaged
livers.
Professor John Iredale, of the MRC Centre for Regenerative
Medicine at the University of Edinburgh, said: "In the first
instance, the successful development of liver cells from embryonic
stem cells will revolutionise and improve the way we are able to
test drugs and novel therapies both for the liver and other organs
and ultimately may lead to a stem cell based approach to regenerate
the live.
"This would have a significant aspect on reducing
the need for donated organs and provide less invasive and traumatic
treatment for those patients for whom transplantation is currently
the only option."
Liver disease is the fifth most common cause of death
in the UK.
The second project, which also involves embryonic
stem cells, will look at new ways to repair damaged bone and cartilage.
The centre's Dr Brendon Noble added: "Cartilage
damage from injury or diseases, such as osteoarthritis, is a major
problem in the UK. If we can prevent cartilage from breaking down
or repair it, then we could potentially reduce the need for hip
replacements."
|